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A rare case of symptomatic creatine kinase elevation in a patient with rheumatoid arthritis treated with baricitinib.
Reumatismo
June 2024
Department of Life, Health and Environmental Sciences University of L'Aquila; Internal Medicine and Nephrology Division, Avezzano-Sulmona-L'Aquila Local Health Authority 1, San Salvatore Hospital, L'Aquila.
The safety profile of baricitinib (BARI), a Janus kinase inhibitor broadly used for the treatment of rheumatoid arthritis (RA), includes asymptomatic laboratory abnormalities, such as an increase in creatine kinase (CK). Data from randomized controlled trials suggest that concomitant myalgia is rare in RA and does not lead to drug discontinuation. We describe the case of a 68-year-old Caucasian female with longstanding, multi-failure RA who started BARI and achieved disease remission.
View Article and Find Full Text PDFThe Lipid Intensive Drug Therapy for Sepsis Phase II Pilot Clinical Trial.
Crit Care Med
August 2024
Department of Medicine, UCLA College of Medicine, Los Angeles, CA.
Objectives: Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with low cholesterol levels would prevent a decline or increase total cholesterol levels at 48 hours.
Design: Phase II, adaptive, randomized pilot clinical trial powered for 48 patients.
Research Note: Effect of fasting time on the fasting heat production, blood metabolites, and body components of layer-type pullets.
Poult Sci
April 2024
Department of Animal Science, Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong, 271018, P. R. China. Electronic address:
Fasting heat production (FHP) is used to assess the maintenance net energy requirement of animals. Herein, the FHP of layer-type pullets was estimated. In trial 1, 16 40-day-old Jingfen layer-type pullets were divided into 4 groups of 4 chickens and placed in 4 respiratory chambers.
View Article and Find Full Text PDFVitamin D was Superior to Omega-3 as a Simvastatin Adjuvant in Improving Blood Lipids and Atherogenic Index in Type-I Dyslipidemic Rats.
Turk J Pharm Sci
January 2024
Hasanuddin University, Faculty of Medicine, Department of Physiology, Makassar, Indonesia.
Objectives: Adjuvant therapy is often used to optimize the antihyperlipidemic effect of simvastatin. Omega-3 and vitamin D supplementation are recommended as adjuvant therapies to low-intensity statins. This study aimed to compare the effects of vitamin D and omega-3 as adjuvant therapy to simvastatin to improve the lipid profiles and atherogenic index of plasma (AIP) in type-I dyslipidemic rats.
View Article and Find Full Text PDFESTIMATION OF VON WILLEBRAND FACTOR IN PATIENTS CARDIAC DISEASES.
Georgian Med News
November 2023
Department of Biochemistry, College of Medicine, Tikrit University, Iraq.
Ischemic heart disease, also called coronary artery disease (CAD), is the term given to heart problems caused by narrowed heart (coronary) arteries that supply blood to the heart muscle.The study aims to determine the levels of Von Willebrand factor in patients with coronary artery disease.A total of 60 CAD patients and 30 healthy individuals were enrolled in the present study.
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