AI Article Synopsis
- Epidermal stem cells play a crucial role in maintaining skin health and aiding recovery after injury.
- Different tests can measure how many stem cells are present and how well they work, but the best measure is their ability to support tissue regeneration over the long term in living organisms.
- Analyzing the effects of specific genetic changes on these stem cells can help determine if they enhance or reduce their regeneration capabilities.
Article Abstract
Epidermal stem cells are responsible for normal tissue homeostasis and contribute to tissue regeneration during injury. Several assays measuring stem cell frequency and function can be used to assess epidermal stem cell potential. However, the ultimate assay that accounts for stemness is the capacity to sustain in vivo long-term tissue regeneration and maintenance. We can use this type of analysis to interrogate whether a specific genetic alteration (e.g., activation or inactivation of any gene thought to be involved in stem cell quiescence or proliferation) confers increased or decreased stem cell potential.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/7651_2019_234 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!