Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912151PMC
http://dx.doi.org/10.1093/cid/ciz361DOI Listing

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