AI Article Synopsis
- The study introduces a low-cost, smartphone-compatible porous silicon biosensor that detects color changes in response to molecular capture in a Porous Silicon microcavity (PSiM).
- The biosensor operates using minimal external accessories, and its accuracy is validated against traditional spectrometer measurements, achieving an equivalent accuracy of 0.33 nm for spectral shifts.
- Demonstrated through a biotin-streptavidin assay, the biosensor has an estimated detection limit of 500 nM, making it a promising tool for label-free point-of-care diagnostics.
Article Abstract
We report a smartphone compatible, low-cost porous silicon biosensor, which correlates the structural colour of a porous silicon microcavity (PSiM) to spectral peak position. Molecules captured in the PSiM cause a colour change that can be quantified through image analysis. Minimal external accessories are employed. Spectrometer measurements of the PSiM reflectance spectrum shifts are carried out concurrently with the smartphone measurements to benchmark the accuracy of the smartphone biosensor. We estimate that the smartphone biosensor supports an equivalent accuracy of 0.33 nm for the detection of colour changes corresponding to spectral shifts of the PSiM. Biosensing functionality is demonstrated using a biotin-streptavidin assay with an estimated detection limit of 500 nM. The PSiM-smartphone biosensor is a promising platform for label-free point of care diagnostics.
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| http://dx.doi.org/10.1039/c9an00022d | DOI Listing |
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