AI Article Synopsis
- The study investigates the process of sexual differentiation in Plasmodium falciparum, which is crucial for malaria transmission, focusing on early gametocyte-committed ring (gc-ring) stages in blood samples from malaria patients.
- Analysis of 260 patient samples reveals that 76% contain gc-rings, with significant variations in the ratio of gametocyte to asexual-committed rings (GCR), influenced by factors like parasitemia and fever.
- The findings highlight the correlation between specific genetic expressions and GCR levels, indicating that clinical factors and gene regulation play important roles in the development of malaria transmission stages in live patients.
Article Abstract
Plasmodium sexual differentiation is required for malaria transmission, yet much remains unknown about its regulation. Here, we quantify early gametocyte-committed ring (gc-ring) stage, P. falciparum parasites in 260 uncomplicated malaria patient blood samples 10 days before maturation to transmissible stage V gametocytes using a gametocyte conversion assay (GCA). Seventy six percent of the samples have gc-rings, but the ratio of gametocyte to asexual-committed rings (GCR) varies widely (0-78%). GCR correlates positively with parasitemia and is negatively influenced by fever, not hematocrit, age or leukocyte counts. Higher expression levels of GDV1-dependent genes, ap2-g, msrp1 and gexp5, as well as a gdv1 allele encoding H are associated with high GCR, while high plasma lysophosphatidylcholine levels are associated with low GCR in the second study year. The results provide a view of sexual differentiation in the field and suggest key regulatory roles for clinical factors and gdv1 in gametocytogenesis in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514009 | PMC |
| http://dx.doi.org/10.1038/s41467-019-10172-6 | DOI Listing |
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