In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field.

Peter W Nagle Marc-Jan van Goethem Marco Kempers Harry Kiewit Antje Knopf Johannes A Langendijk Sytze Brandenburg Peter van Luijk Rob P Coppes

Radiother Oncol

Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address:

Published: August 2019

Research investigated the effects of a magnetic field on proton therapy to enhance beam delivery and treatment precision.
The study focused on cancer cell lines and organoid models derived from stem cells.
Findings indicated that the presence of a magnetic field does not alter biological responses to proton irradiation.

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response.

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http://dx.doi.org/10.1016/j.radonc.2019.04.028	DOI Listing

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