AI Article Synopsis
- * These compounds consist of hundreds of distinct lipid species, primarily analyzed using advanced techniques like (U)HPLC-MS for accurate quantification.
- * Understanding factors that contribute to both analytical and biological variability of oxylipin profiles is essential for improving their reliability in clinical research, and this review provides guidance to enhance comparability and interpretation across studies.
Article Abstract
Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in numerous physiological and pathological processes. Therefore, their quantitative profiling has gained a lot of attention during the last years notably in the active field of health biomarker discovery. Oxylipins include hundreds of structurally and stereochemically distinct lipid species which today are most commonly analyzed by (ultra) high performance liquid chromatography-mass spectrometry based ((U)HPLC-MS) methods. To maximize the utility of oxylipin profiling in clinical research, it is crucial to understand and assess the factors contributing to the analytical and biological variability of oxylipin profiles in humans. In this review, these factors and their impacts are summarized and discussed, providing a framework for recommendations expected to enhance the interlaboratory comparability and biological interpretation of oxylipin profiling in clinical research.
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| http://dx.doi.org/10.1016/j.freeradbiomed.2019.05.012 | DOI Listing |
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