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Article Abstract
Background: Sepsis is the leading cause of morbidity and mortality in newborns. CD64 combined with c-reactive protein (CRP) could improve the sensitivity and specificity of neonatal sepsis diagnosis, but the results were still controversial. Therefore, this meta-analysis was conducted to clarify the importance of CD64 combined with CRP in the diagnosis of neonatal sepsis.
Methods: The researches published as of December 24, 2018 were comprehensively searched in PubMed, Embase (included Embase and Medline), the Cochrane Library and Web of Science. Totally, 8 articles were included, involving 1114 objects. Statistical calculations were performed using Stata14.0 and Review Manager 5.3.
Results: The diagnostic accuracy of all included studies was pooled as follows: sensitivity, 0.95 (95% CI: 0.86-0.98); specificity, 0.86 (95% CI: 0.74-0.93); positive likelihood ratio (PLR), 6.8 (95% CI: 3.50-13.20); negative likelihood ratio (NLR), 0.06 (95% CI: 0.02-0.18); diagnostic odds ratio (DOR), 118.0 (95% CI: 25.00-549.00), and the area under the curve (AUC) was 0.96 (95% CI: 0.94-0.97). It was found that heterogeneity was not caused by threshold effect (P = 0.16), but the results of sensitivity (I = 87.57%) and specificity (I = 89.07%) analyses indicated significant heterogeneity between studies.
Conclusions: The combined application of CD64 and CRP improved the accuracy of neonatal sepsis diagnosis.
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| http://dx.doi.org/10.1016/j.ajem.2019.05.001 | DOI Listing |
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- - Sepsis is a severe immune reaction to infection that can lead to organ failure, and while current diagnostic methods exist, there's a need for quicker and more precise tests to improve survival rates.
- - Researchers developed a 3D-printed microfluidic chip designed to capture specific sepsis cells in blood samples using antibodies CD69, CD64, and CD25, validating its effectiveness with clinical samples from 125 septic patients and 10 healthy individuals.
- - The chip showed significant differences in antigen cell counts between healthy volunteers and septic patients, with a high diagnostic accuracy (AUC values exceeding 0.988 for individual markers and 0.997 for a combined panel), and offered results within 4 hours, much faster
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