Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans.

Pomegranate juice with a high content of polyphenols, pomegranate extract, ellagic acid, and urolithin A, have anti-oxidant and anti-obesity effects in humans. Pomegranate juice extends lifespan of . () (n = 6) compared to the control group in each treatment, lifespan was increased by pomegranate juice in wild type (N2, 56 %, P < 0.001) and mutant () (18 %, P = 0.00012), by pomegranate extract in N2 (28 %, P = 0.00004) and in (10 %, P < 0.05), or by ellagic acid (11 %, P < 0.05). Pomegranate juice reduced intestinal fat deposition (IFD) in (n = 10) N2 (-68 %, P = 0.0003) or in the (-33 %, P = 0.0034). The intestinal fat deposition was increased by pomegranate extract in N2 (137 %, P < 0.0138) and in (26 %, P = 0.0225), by ellagic acid in N2 (66 %, P < 0.0001) and in (74 %, P < 0.0001), or by urolithin A in N2 (57 %, P = 0.0039) and in (43 %, P = 0.0001). These effects were partially mediated by the pathway. The data may offer insights to human aging and obesity due to homology with .