AI Article Synopsis
- Plasmonic photo-thermal therapy (PPTT) utilizes noble metal nanoparticles, particularly gold nanorods (GNRs), to convert light into heat for medical applications, including antimicrobial treatment.
- The study focuses on the effectiveness of GNRs as a heat-generating agent under laser irradiation, accentuating the importance of controlling GNR concentration to minimize cytotoxic effects.
- Results indicate that the GNRs can safely increase local temperatures to approximately 50 °C in five minutes, achieving a significant reduction of bacteria by about 2 log CFU.
Article Abstract
Plasmonic photo-thermal therapy (PPTT) is a minimally invasive, drug-free, therapy based on the properties of noble metal nanoparticles, able to convert a bio-transparent electromagnetic radiation into heat. PPTT has been used against cancer and other diseases. Herein, we demonstrate an antimicrobial methodology based on the properties of gold nanorods (GNRs). Under a resonant laser irradiation GNRs become highly efficient light to heat nano-converters extremely useful for PPTT applications. The concept here is to assess the antimicrobial effect of easy to synthesize, suitably purified, water-dispersible GNRs on bacteria. A control on the GNRs concentration used for the process has been demonstrated critical in order to rule out cytotoxic effects on the cells, and still to be able to generate, under a near infrared illumination, an adequate amount of heat suited to increase the temperature up to ≈50 °C in about 5 min. Viability experiments evidenced that the proposed system accomplished a killing efficiency suitable to reducing the population of about 2 log CFU (colony-forming unit).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539421 | PMC |
| http://dx.doi.org/10.3390/ma12091530 | DOI Listing |
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