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Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification. | LitMetric

Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification.

Bioorg Med Chem

Graduate School of Life Science, Frontier Research Center for Advanced Material & Life Science, Hokkaido University, N21, W11, Sapporo 001-0021, Japan; Medicinal Chemistry Pharmaceuticals Co. Ltd., Sapporo, Japan.

Published: July 2019

AI Article Synopsis

Article Abstract

Structural and functional effects of core M1 type glycan modification catalyzed by protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) were investigated using a core M1 glycoform focused library of an α-dystroglycan fragment, TRGAIIQTPTLGPIQPTRV. Evanescent-field fluorescence-assisted microarray system illuminated the specific binding pattern of plant lectins that can discriminate the glycan structure of core M1 glycan of the library. The comparative NMR analysis of synthetic glycopeptide having different length of the O-mannosylated glycans revealed a conformational change of the peptide backbone along with core M1 disaccharide formation. No long-range NOE signals of glycan-amino acid nor inter amino acid indicate the conformational change is induced by steric hindrance of core M1, the sole 1,2-O-modified form among protein binding sugar residue found in mammals.

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Source
http://dx.doi.org/10.1016/j.bmc.2019.05.008DOI Listing

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