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How Pediatric Readiness can Impact Pediatric Trauma From Every Day to Mass Events.
J Pediatr Surg
January 2025
Mary Bridge Children's, Department of Pediatric Surgery and Pediatric Trauma, Tacoma, WA, USA.
Disaster events such as weather events and mass casualty events are increasing in frequency and severity. Caring for children during a surge requires a regional approach given limited pediatric inpatient capacity and expertise. During the 2024 American Academy of Pediatrics National Convention and Exhibition, the Section on Surgery and Council on Children and Disasters (COCD) partnered to present a joint symposium emphasizing importance of pediatric readiness and disaster preparedness and role of pediatric trauma surgeons in disaster preparedness and response in all communities.
View Article and Find Full Text PDF>6°(C) of separation: Exploring the difference between perceived and measured temperature.
J Therm Biol
January 2025
School of Geography, Archaeology and Environmental Studies, University of the Witwatersrand, Private Bag X3, Wits, 2050, South Africa. Electronic address:
Questionnaires exploring tourists' perceptions of ideal climatic conditions are argued to be a more suitable data source for the development of tourism climate indices than the utilization and integration of expert opinion and pre-established thresholds. This assumes that those tourist respondents can accurately quantify meteorological conditions at a given point in time, and effectively discriminate between meteorological thresholds of suitable and unsuitable conditions. For variables such as rainfall and sunshine hours, this assumption is fairly reasonable.
View Article and Find Full Text PDFJanus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats.
J Autoimmun
January 2025
University of Massachusetts Chan Medical School, Department of Medicine, Diabetes Center of Excellence, USA. Electronic address:
Numerous studies highlight the essential role of type I interferon (IFN) responses in type 1 diabetes. The absence of type I IFN signaling is associated with a partial reduction of autoimmune diabetes incidence in LEW.1WR1 rats.
View Article and Find Full Text PDFEvaluating student understanding of core pharmacokinetic concepts.
Eur J Pharmacol
January 2025
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Australia. Electronic address:
Both educators and graduates have expressed concern about a perceived pharmacology knowledge gap that includes difficulty applying fundamental principles to clinical and research problems. Consequently, we sought to determine the extent to which current students can explain the meaning of, and appropriately apply, a subset of core concepts, and to identify any misconceptions arising from the responses. Of the twenty-four pharmacology core concepts arising from the recent international collaboration, four pharmacokinetic concepts were chosen, namely drug bioavailability, drug clearance, volume of distribution, and steady-state concentration.
View Article and Find Full Text PDFDendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer.
bioRxiv
December 2024
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attractive therapeutic targets. However, the mechanisms regulating TLS formation and maintenance in cancer are incompletely understood.
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