Characterization of thalassemia major and diabetes mellitus patients at a reference center in Brazil.

Hematol Transfus Cell Ther

Instituto de Ciências Matemáticas e de Computação da Universidade de São Paulo (ICMC-USP), São Carlos, SP, Brazil.

Published: December 2018

AI Article Synopsis

  • This study examined the sociodemographic and clinical traits of thalassemia major patients, focusing on those with and without diabetes, involving 31 patients from a Brazilian treatment center in 2016.
  • About 16.1% of these patients had diabetes, with an average age of 35, predominantly being students or new entrants in the job market and most commonly treated with oral desferasirox.
  • Findings indicated that diabetic patients showed abnormal levels in fasting glucose, liver enzymes, and bone health assessments, highlighting the need for tailored educational strategies for effective care management.

Article Abstract

Objective: This is a quantitative transversal study that aimed to analyze the sociodemographic and clinical characteristics of thalassemia major patients with and without diabetes mellitus.

Method: The cohort consisted of 31 thalassemia major patients from a reference center of treatment in Brazil in 2016. The data were obtained from an interview using a questionnaire containing demographic and clinical variables. The results show that 16.1% of the participants with thalassemia major had diabetes mellitus. The participants' ages ranged from 20 to 48 years, with an average of 35 years, mostly students and starting in the formal job market. The most commonly used treatment was the oral desferasirox and the transfusion treatment interval was 15-22 days.

Results: Patients with thalassemia major and diabetes mellitus presented altered values of fasting glycemia, serum alanine transaminase, magnetic resonance imaging and bone densitometry.

Conclusion: It was concluded that knowledge of the characteristics of this population contributes in the proposal of effective educational strategies in light of the complexity of care and the progression of the disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517619PMC
http://dx.doi.org/10.1016/j.htct.2018.08.005DOI Listing

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