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Associations of HLA-G 3'UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis.
Immunobiology
December 2024
Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address:
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen (HLA)-G 3'UTR polymorphisms and the expression of HLA-G in both tumor tissues and plasma samples from patients with GC in the Tunisian population.
Methods: HLA-G 3'UTR polymorphisms (14pb Insertion/deletion and + 3142C/G) were identified by polymerase chain reaction (PCR) or Sanger sequencing.
Article Synopsis
- - The study investigates the nutritional status of breast cancer patients undergoing chemotherapy and explores how nutrition affects the severity of chemotherapy-related digestive issues.
- - Conducted on 107 women with an average age of 52, the study found that 41% were malnourished, 80% experienced constipation, and strong adherence to a Mediterranean diet was linked to less severe nausea and constipation.
- - The results emphasize the importance of early nutritional intervention to enhance the tolerance and effectiveness of chemotherapy treatments in breast cancer patients.
Lung stereotactic radiation therapy: Early results from the Salah Azaiez Institute.
Tunis Med
November 2024
Department of Radiation Oncology, Salah Azaiz Institute, Tunis, Tunisia.
Article Synopsis
- - SBRT is a cutting-edge treatment for lung cancer that minimizes damage to healthy tissue and has improved patient care at the Salah Azaiez Institute through a thorough study of lung cancer patients.
- - The study analyzed 10 lung cancer patients from 2019 to 2022, focusing on their demographics, tumor characteristics, and treatment plans, finding that most patients were older males with varying stages of lung cancer including inoperable tumors and oligometastatic disease.
- - After treatment, patients experienced some acute side effects like cough and fatigue, but with no severe complications or local recurrences noted after a follow-up period, indicating that SBRT is promising yet still requires careful planning and management.
Decoding the pathological and genomic profile of epithelial ovarian cancer.
Sci Rep
November 2024
Laboratory of Predictive Oncology, Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix Marseille Université U105, Marseille, France.
Ovarian cancer (OC) is one of the most common cancers in women, with a high mortality rate. Most of published studies have been focused on Caucasian populations, with the need to explore biological features and clinical outcomes of patients from other ethnicities. We described clinical outcome (progression-free survival and overall survival) and biomarkers associated with survival in a cohort of patients with OC from Tunisia.
View Article and Find Full Text PDFBasosquamous Carcinoma Arising from the Vulva: A Case Report.
Case Rep Oncol
November 2024
Faculty of Medicine of Tunis, University of Tunis Manar, Tunis, Tunisia.
Article Synopsis
- * A case study of a 59-year-old woman showed a painful, slow-growing vulvar lesion diagnosed as BSC, confirmed by biopsy and treated with partial radical vulvectomy and sentinel lymph node biopsy, both showing no evidence of metastasis.
- * This case highlights the importance of recognizing squamous differentiation in BSC for ensuring complete surgical excision, as it has a higher risk of recurrence and metastasis compared to basal cell carcinoma,
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