Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaad.2019.05.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Obesity is a metabolic disease that is marked by excessive fat accumulation and is objectively defined as a body mass index (BMI) ≥30 kg/m2. Obesity is associated with several other comorbidities, including psoriasis, which is a chronic autoimmune skin disease. Adipocytes produce pro-inflammatory signaling molecules, namely adipokines and classic cytokines, that drive increased inflammation axnd may contribute to the pro-inflammatory pathways driving psoriasis disease pathogenesis.
View Article and Find Full Text PDFRisk of Candida and overall fungal infections with interleukin-17 inhibitors in the treatment of hidradenitis suppurativa: A systematic review and meta-analysis.
J Am Acad Dermatol
December 2024
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Division of Dermatology, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Article Synopsis
- * The study evaluates the effectiveness and safety of various treatments for non-radiographic axial spondyloarthritis (nr-axSpA), including tumour necrosis factor inhibitors (TNFi), interleukin-17 inhibitors (IL-17i), and Janus kinase inhibitors (JAKi).
- * A systematic review covered 10 randomized controlled trials with 2,418 participants, utilizing multiple databases and statistical software to analyze data on treatment efficacy and adverse events.
- * Results showed that certolizumab pegol was the most effective, followed by other treatments like golimumab and bimekizumab, with most therapies significantly improving symptoms compared to placebo; however, safety profiles varied among treatments.
Systematic review of biologic use for psoriasis in HIV-positive individuals from 2018 to 2024.
Arch Dermatol Res
November 2024
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- - Psoriasis is a long-term inflammatory skin condition linked to T-lymphocyte activation, and treating it in individuals with HIV is challenging due to immune system complications.
- - This study reviewed 19 articles involving 24 cases of psoriasis in people with HIV, analyzing various therapies like apremilast and ustekinumab, which showed effectiveness in reducing skin symptoms and even some cases of psoriatic arthritis.
- - Although adverse events were rare and manageable, more comprehensive research is needed to clearly understand the safety and efficacy of these treatments for HIV-positive patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!