AI Article Synopsis
- Brain serotonin is important for understanding aggressive behavior, and the way it affects aggression is still not fully understood.
- In a study involving Tph2 knockout (KO) rats with low serotonin levels, researchers found these rats were more aggressive than normal Tph2 wildtype (WT) rats, but not as aggressive as feral wild type Groningen (WTG) rats.
- Testing a serotonin receptor agonist, NLX-112, revealed that Tph2 KO rats have reduced sensitivity to serotonin receptors compared to Tph2 WT and WTG rats, challenging previous findings in Tph2 KO mice.
Article Abstract
Brain serotonin (5-HT) plays a key role in aggressive behaviours and related psychopathologies, but its precise mechanism of action remains elusive. Genetic animal models may provide a tool to elucidate the relationship between aggression and serotonin. The present study showed that tryptophan hydroxylase 2 (Tph2) knockout (KO) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their Tph2 wildtype (WT) counterparts. However, the level of aggression in Tph2 KO rats did not equal that of feral wild type Groningen (WTG) rats. To investigate whether enhanced 5-HT receptor functionality may be present in Tph2 KO rats, we tested the acute anti-aggressive potency of the highly selective 5-HT receptor full agonist NLX-112 (a.k.a. befiradol or F13640). Data show that compared to Tph2 WT and WTG rats, the NLX-112 dose-effect curve was shifted to the right in Tph2 KO animals. These results suggest that, unlike previous reports in Tph2 KO mice, Tph2 KO rats have a decreased 5-HT receptor sensitivity compared to both Tph2 WT and WTG animals.
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| http://dx.doi.org/10.1016/j.neuropharm.2019.05.004 | DOI Listing |
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