AI Article Synopsis
- Four angucycline glycosides were previously identified from the marine-derived strain OC1610.4, leading to the discovery of two new glycosides, vineomycins E and F, along with five known ones during further studies with different fermentation media.
- Among the isolated compounds, vineomycin F features a unique ring-cleavage deoxy sugar.
- The cytotoxic effects of these glycosides were tested on breast cancer cell lines, with moromycin B, saquayamycin B, and saquayamycin B showing strong anti-cancer activity, particularly saquayamycin B, which also inhibited the migration of aggressive MDA-MB-231 cells.
Article Abstract
Four angucycline glycosides were previously characterized from marine-derived sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F (-), and five known homologues, grincamycin L (), vineomycinone B (), fridamycin D (), moromycin B (), and saquayamycin B (). Vineomycin F () contains an unusual ring-cleavage deoxy sugar. All the angucycline glycosides isolated from sp. OC1610.4 were evaluated for their cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231, and BT-474. Moromycin B (), saquayamycin B (), and saquayamycin B () displayed potent anti-proliferation against the tested cell lines, with IC values ranging from 0.16 to 0.67 μM. Saquayamycin B () inhibited the migration and invasion of MDA-MB-231 cells in a dose-dependent manner, as detected by Transwell and wound-healing assays.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562490 | PMC |
| http://dx.doi.org/10.3390/md17050277 | DOI Listing |
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