N6-Methyladenosine (mA) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. mA RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA), microRNA (miRNA) and long noncoding RNA (lncRNA). And mA methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that mA RNA modification highly regulates hepatic function and development of liver diseases. Here, we aim to summarize the biological and clinical significance of mA modification in hepatic growth and hepatic disease including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and liver cancer.
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| http://dx.doi.org/10.1016/j.ab.2019.05.005 | DOI Listing |
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