AI Article Synopsis
- Endometrial cancer is the most prevalent gynecologic cancer in the U.S., with increasing rates of incidence.
- Despite recent advancements in understanding its biology, treatment controversies persist, especially regarding surgical lymph node assessment and patient selection for additional therapies like radiation or chemotherapy.
- Pembrolizumab, an immunotherapy for microsatellite-instable, metastatic endometrial cancer, has received FDA approval, and ongoing trials aim to further explore its potential.
Article Abstract
Endometrial cancer is the most common gynecologic cancer in the United States, and its incidence is rising. Although there have been significant recent advances in our understanding of endometrial cancer biology, many aspects of treatment remain mired in controversy, including the role of surgical lymph node assessment and the selection of patients for adjuvant radiation or chemotherapy. For the subset of women with microsatellite-instable, metastatic disease, anti- programmed cell death protein 1 immunotherapy (pembrolizumab) is now approved by the US Food and Drug Administration, and numerous trials are attempting to build on this early success.
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| http://dx.doi.org/10.3322/caac.21561 | DOI Listing |
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