Wavefront-propagation simulations have been performed to complete the design of a monochromator beamline for FLASH2, the variable-gap undulator line at the soft X-ray free-electron laser in Hamburg (FLASH). Prior to propagation through the beamline optical elements, the parameters of the photon source were generated using the GENESIS code which includes the free-electron laser experimental data. Threshold tolerances for the misalignment of mirror angles are calculated and, since diffraction effects were included in the simulations, the minimum quality with respect to the slope errors required for the optics is determined.
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http://dx.doi.org/10.1107/S160057751900345X | DOI Listing |
PLoS One
December 2024
Department of Electrical, Computer and Software Engineering, The University of Auckland, Auckland, New Zealand.
Computational models of the cell can be used to study the impact of drugs and assess pathological risks. Typically, these models are computationally demanding or challenging to implement in dedicated hardware for real-time emulation. A new Frequency Modulation (FM) model is proposed to address these limitations.
View Article and Find Full Text PDFNeural Netw
November 2024
Institute of Physics, Saratov State University, 83 Astrakhanskaya str., 410012 Saratov, Russia. Electronic address:
The widespread development and use of neural networks have significantly enriched a wide range of computer algorithms and promise higher speed at lower cost. However, the imitation of neural networks by means of modern computing substrates is highly inefficient, whereas physical realization of large scale networks remains challenging. Fortunately, delayed-feedback oscillators, being much easier to realize experimentally, represent promising candidates for the empirical implementation of neural networks and next generation computing architectures.
View Article and Find Full Text PDFThe advanced Kirkpatrick-Baez (AKB) mirror setup is an effective and compelling solution to provide stable X-ray nano-focusing for synchrotron radiation or free-electron laser beamlines. We propose an AKB mirror design optimization approach to mitigate the difficulties associated with mirror fabrication by minimizing the total slope ranges of the four curved mirrors while achieving the expected focusing performance. In the optimization, we have considered geometry constraints to ensure the beam acceptance with the required clear aperture, the diffraction-limited focal size with the adequate numerical aperture, and the desired mirror gaps for adjustment and the necessary working distance for the sample stage.
View Article and Find Full Text PDFMath Biosci
December 2024
MATBIOM, Universidad de Medellin, Medellin, Colombia.
Atrial fibrillation (AF) is the most common cardiac arrhythmia with mechanisms of initiation and sustaining that are not fully understood. The clinical procedure for AF contemplates the analysis of the atrial electrograms, whose morphology has been correlated with the underlying structure of the atrial myocardium. This study employs a mathematical model incorporating fractional calculus to simulate cardiac electrical conduction, accounting for tissue structural inhomogeneities using complex-valued orders.
View Article and Find Full Text PDFCurr Opin Cardiol
January 2025
Cortex Inc, Menlo Park, California, USA.
Purpose Of Review: A low ceiling of efficacy exists for the treatment of persistent atrial fibrillation via pulmonary vein isolation without adjunctive ablations, which is likely because they do not target an individual patient's specific underlying disease mechanisms. Electrographic flow (EGF) mapping is the first system that reliably displays wavefront propagation through the atria. It is a promising tool for localizing sources of atrial fibrillation, guiding targeted ablation, and visualizing conduction through the atrial substrate.
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