AI Article Synopsis
- Allostatic load refers to the wear and tear on the body's systems due to repeated stress responses, increasing vulnerability to health issues.
- The model suggests that physiological changes can occur long before any illnesses become evident, prompting researchers to focus on early signs of stress-related dysfunction.
- This review aims to summarize research on how stress and its mediators contribute to cognitive decline, emphasizing the role of manageable risk factors.
Article Abstract
Allostatic load is defined as the frequent activation of the neuroendocrine, immunological, metabolic and cardiovascular systems, which makes individuals more susceptible to stress-related health problems. According to this model, physiological dysregulations start to emerge decades before diseases manifest. Consequently, stress research has shifted its attention to anticipating the degree of this dysregulation to better understand the impact of stress hormones and other biomarkers on disease progression. In view of the growing number of studies that demonstrate the influence of modifiable risk factors on cognitive decline, in addition to the effects of chronic stress mediators, the objective of the present review was to present an overview of the development of cognitive changes based on studies on stress and its mediators.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497016 | PMC |
| http://dx.doi.org/10.1590/1980-57642018dn13-010002 | DOI Listing |
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