Daminozide (Alar) was found to produce N-nitrosodimethylamine (NDMA) and N-nitrodimethylamine (NITDMA) when treated with nitrite in acidic solution. Unsymmetrical dimethylhydrazine (UDMH), the hydrolysis product of Daminozide, gave the same products. Use of N-nitrite and N-Daminozide showed that both the nitroso group of NDMA and the nitro group of NITDMA arise from the nitrite.
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Effects of plant growth retardant daminozide (Alar) on neuromuscular co-ordination behavior in .
J Toxicol Environ Health A
November 2022
Department of Zoology, University of Calcutta, Kolkata, India.
Daminozide (alar), a plant growth retardant, is used in different fruit orchard to make fruits attractive and reduce pre-harvest losses. Previously data demonstrated that acute daminozide exposure affected reproductive fitness and produced neurodegeneration in . The goal of this study was to determine whether continuous exposure to daminozide affects neuromuscular co-ordination in as manifested in various behavioral responses.
View Article and Find Full Text PDFGenes regulating wing patterning in Drosophila melanogaster show reduced expression under exposure of Daminozide, the fruit ripening retardant.
Environ Toxicol Pharmacol
April 2020
Cytogenetics & Genomics Research Unit, Department of Zoology, University of Calcutta, Taraknath Palit Sikshaprangan, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019 India. Electronic address:
In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed to explore the metabolic modification of Daminozide following ingestion, the effects of Daminozide on the expression of genes which are pivotal for wing development and molecular interactions of Daminozide with those proteins involved in wing patterning. We demonstrated through reporter gene construct assay using X-gal staining method and transgenic Drosophila melanogaster stocks that the vestigial, wingless and decapentaplegic genes in wing imaginal disc from 3 instar larvae exhibited reduced expression when exposed to Daminozide in compare to control larvae.
View Article and Find Full Text PDFComparative tomographic study of the S2-alar-iliac screw versus the iliac screw.
Eur Spine J
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Department of Orthopedics and Traumatology, IOT HCFMUSP, 171 Dr. Ovídio Pires de Campos St., São Paulo, SP, 05403010, Brazil.
Article Synopsis
- Iliac screws and S2-alar-iliac screws are becoming popular for fixing lumbosacral spine issues, but there's limited research on their optimal positioning.
- This study involved analyzing CT images from 25 patients to compare the insertion parameters of both screw techniques, focusing on measurements like length and depth.
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Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism melanogaster.
Interdiscip Toxicol
May 2018
Cytogenetics & Genomics Research Unit, Department of Zoology, University of Calcutta, Kolkata 700019, India.
Alar (Daminozide) is a plant growth regulator which is widely used as a fruit preservative for apple and mango to prevent pre-harvest fruit drop, promote color development and to delay excessive ripening. The aim of the present work was to demonstrate the effect of Alar on several life history traits, adult morphology, Hsp70 protein expression and DNA damage in the brain of the model organism . We assessed the life history and morphological traits including fecundity, developmental time, pupation height, egg-to-adult viability and mean wing length, body length, arista length and sternopleural bristle number of the emerging flies.
View Article and Find Full Text PDFTransformation of the plant growth regulator daminozide (Alar) and structurally related compounds with CuII ions: oxidation versus hydrolysis.
Environ Sci Technol
May 2003
Department of Geography and Environmental Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
As part of a study of metal ion effects on chemical transformations of nitrogen-containing agrochemicals, conversion of daminozide to succinate via cleavage of the hydrazide C-N bond was examined in the presence and absence of divalent metal ions. No conversion was observed in metal ion-free solutions or in the presence of 1.0 mM NiII, ZnII, and PbII.
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