AI Article Synopsis
- A study evaluated the susceptibility of 37 isolates of Hortaea werneckii, responsible for tinea nigra, to nine antifungal agents from both clinical and environmental sources.
- Posaconazole showed the most effectiveness with the lowest minimum inhibitory concentration (MIC) at 0.07 µg/mL, followed by voriconazole and isavuconazole.
- In contrast, fluconazole had the highest MIC at 14.56 µg/mL, indicating it is less effective against H. werneckii, along with caspofungin and anidulafungin also showing high MICs.
Article Abstract
The in vitro susceptibility of molecularly identified Hortaea werneckii isolates (n = 37), the causative agent of tinea nigra, originating from clinical and environmental sources was determined for nine antifungal agents. Posaconazole had the lowest geometric mean minimum inhibitory concentration (GM MIC) (0.07 µg/mL), followed by voriconazole (0.13 µg/mL), isavuconazole (0.14 µg/mL), itraconazole (0.16 µg/mL), terbinafine (0.19 µg/mL) and amphotericin B (0.92 µg/mL). In contrast, fluconazole (14.56 µg/mL), caspofungin (2.41 µg/mL) and anidulafungin (1.42 µg/mL) demonstrated the highest GM MICs/MECs against H. werneckii.
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| http://dx.doi.org/10.1016/j.ijantimicag.2019.05.006 | DOI Listing |
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