The haemodynamic effects of two vasodilators, sublingual nitroglycerine and nifedipine, on absolute end-diastolic volume, end-systolic volume, stroke volume (SV), heart rate, systolic blood pressure (SBP), cardiac output (CO) and corresponding cardiac indices were measured in two different groups, each consisting of 20 ischaemic heart disease patients, with gated blood pool scintigraphy. A control study was done in 5 ischaemic heart disease patients without intervention. Direct measurement of left ventricular (LV) volume was done by correcting LV activity for tissue attenuation utilising a geometric method. With nifedipine intervention only SBP (125.25 +/- 19.8 mmHg) showed a significant mean decrease (11 mmHg). The other measured parameters did not change significantly. With nitroglycerine all the parameters except LV ejection fraction showed significant changes. Mean CO decreased by 8% while mean SV decreased by 16%. The results in the control group showed excellent repeatability. The absolute haemodynamic changes of future cardiac drugs might easily be measured in vivo by this non-invasive technique.
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