AI Article Synopsis
- Adipose tissue is recognized as both an energy reserve and a hormonal organ, producing adipocytokines that impact various bodily processes and are linked to diseases like chronic kidney disease (CKD).
- Zinc α2-glycoprotein (ZAG) is emerging as a potential connection between adipose tissue and CKD, contributing to malnutrition in dialysis patients, which raises mortality rates.
- ZAG may serve as a new biomarker for kidney damage, and targeted treatments could help reduce the harmful effects of cachexia in these patients.
Article Abstract
Adipose tissue is currently considered not only as an energy store but also as an organ of internal secretion. Numerous adipocytokines regulating a number of human body processes are important in many disease processes, including chronic kidney disease (CKD). Nowadays, the role of zinc α2-glycoprotein (ZAG) is being sought as a potential link between these two organs. ZAG, through its lipolytic effect, contributes to progressive malnutrition in patients undergoing dialysis, and this significantly increases their mortality. It seems that ZAG may be a new potential biomarker of kidney damage, and the specific pharmacotherapy will significantly reduce the progressive process of cachexia.
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| http://dx.doi.org/10.5603/EP.a2018.0085 | DOI Listing |
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