AI Article Synopsis
- β-Glycoprotein I is a key protein involved in antiphospholipid syndrome (APS), a disorder that leads to blood clots and can cause complications in pregnancy.
- In healthy individuals, β-glycoprotein I exists in a balanced ratio of oxidized and reduced forms, but this balance is disrupted in conditions like APS, age-related macular degeneration, and septic infections.
- Researchers have created tests to measure the levels of different forms of β-glycoprotein I in blood, which may help in assessing risks and predicting outcomes in these medical conditions.
Article Abstract
β-Glycoprotein I is the major autoantigen in the antiphospholipid syndrome (APS), a prothrombotic disorder characterized by the occurrence of either venous or arterial thrombosis. In women it is also associated with an increased risk of obstetric complications such as recurrent miscarriages. We have identified that the plasma protein β-glycoprotein I in healthy individuals exists in an optimal ratio between two distinct forms, an oxidized and free thiol, reduced form. This ratio is disrupted in pathophysiological conditions associated with increased oxidative stress such as the APS, but also in the setting of age-related macular degeneration and gram-negative sepsis. We have developed assays that quantify plasma/serum levels of total and free thiol β-glycoprotein I which can potentially be used for risk stratification and prognostic purposes in the early stages of the aforementioned conditions.
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| http://dx.doi.org/10.1007/978-1-4939-9187-7_17 | DOI Listing |
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