Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABAR subunits.

Commun Biol

2Department of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch, Galveston, TX USA.

Published: April 2020

Altered expression of GABA receptors (GABARs) has been implicated in neurological and psychiatric disorders, but limited information about region-specific GABAR subunit expression in healthy human brains, heteromeric assembly of major isoforms, and their collective organization across healthy individuals, are major roadblocks to understanding their role in non-physiological states. Here, by using microarray and RNA-Seq datasets-from single cell nuclei to global brain expression-from the Allen Institute, we find that transcriptional expression of GABAR subunits is anatomically organized according to their neurodevelopmental origin. The data show a combination of complementary and mutually-exclusive expression patterns that delineate major isoforms, and which is highly stereotypical across brains from control donors. We summarize the region-specific signature of GABR subunits per subject and its variability in a control population sample that can be used as a reference for remodeling changes during homeostatic rearrangements of GABAR subunits after physiological, pharmacological or pathological challenges.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494906PMC
http://dx.doi.org/10.1038/s42003-019-0413-7DOI Listing

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