Introduction: Response to preoperative chemoradiation (PRTCT) for rectal cancer predicts the long-term outcome.
Context: Tertiary care hospital.
Aims: The aim is to study the factors affecting the response to chemoradiation.
Settings And Design: Retrospective.
Materials And Methods: Twenty-three patients of rectal cancer undergoing PRTCT followed by surgery and adjuvant chemotherapy were followed up for 20-56 months. Postoperative response, tumor downstaging and nodal downstaging were correlated with the disease status.
Results: Tumor downstaging was seen in 11 (50%) and nodal downstaging in 12 (63.15%) patients. Nodal downstaging was statistically significant with = 0.004. Pathological complete response (PCR) was seen in one patient and partial response (PR) in 17 patients. Thirteen (72.2% of patients) were alive and disease free and the negative nodal status correlated with long-term control with = 0.04.
Conclusion: Most patients of rectal cancer show PR to PRTCT, and the benefit is more for node-positive patients. Nodal PCR is associated with a higher chance of long-term disease control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498706 | PMC |
| http://dx.doi.org/10.4103/sajc.sajc_203_17 | DOI Listing |
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