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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats. | LitMetric

AI Article Synopsis

  • Glycerol injections in rats cause rhabdomyolysis, leading to the release of muscle content into the bloodstream and acute kidney injury (AKI), influenced by oxidative stress and inflammation.
  • A study evaluated how calcitriol (a form of vitamin D) affects AKI caused by rhabdomyolysis by treating rats with calcitriol or saline and monitoring kidney function and damage.
  • Results showed that glycerol-injected rats experienced significant kidney injury and inflammation, but those treated with calcitriol exhibited less damage, indicating its potential protective effects against oxidative stress and inflammatory responses.

Article Abstract

Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular muscle content to the extracellular compartment and acute kidney injury (AKI). Oxidative stress and the inflammatory processes contribute to the disturbances in renal function and structure observed in this model. This study evaluated the effect of calcitriol administration in AKI induced by rhabdomyolysis and its relationship with oxidative damage and inflammatory process. Male Wistar Hannover rats were treated with calcitriol (6 ng/day) or vehicle (0.9% NaCl) for 7 days and were injected with 50% glycerol or saline 3 days after the beginning of calcitriol or saline administration. Four days after glycerol or saline injection, urine, plasma and renal tissue samples were collected for renal function and structural analysis. The oxidative stress and the inflammatory processes were also evaluated. Glycerol-injected rats presented increased sodium fractional excretion and decreased glomerular filtration rates. These alterations were associated with tubular injury in the renal cortex. These animals also presented increased oxidative damage, apoptosis, inflammation, higher urinary excretion of vitamin D-binding protein and decreased cubilin expression in renal tissue. All these alterations were less intense in calcitriol-treated animals. This effect was associated with decreases in oxidative damage and inflammation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506495PMC
http://dx.doi.org/10.1038/s41598-019-43564-1DOI Listing

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