Arabidopsis () floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of (), which is essential for stem cell maintenance. At floral stage 6, is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repress through histone deacetylation; however, how the changes in the chromatin state of are initiated and maintained to terminate the floral meristem remains elusive. Here, we show that KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of After KNU is induced, it binds to the promoter and causes eviction of SPLAYED, which is a known activator of and can oppose polycomb repression. KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of This multi-step silencing of leads to the termination of floral stem cells, ensuring proper carpel development. Thus, our work describes a detailed mechanism for heritable floral stem cell termination in a precise spatiotemporal manner.
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| http://dx.doi.org/10.1105/tpc.18.00450 | DOI Listing |
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