A sequence of a Baeyer-Villiger oxidation and a Lewis acid-promoted reduction of the resulting formate with Et SiH enabled the metal-free formal decarbonylation of tertiary and secondary aliphatic aldehydes. The new methodology mimics the biosynthetic decarbonylation pathway through oxidative C-C bond cleavage rather than the C(O)-H bond activation known from conventional Tsuji-Wilkinson-type reactions. The substrate scope is complementary to existing transition-metal-catalyzed protocols.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201902082 | DOI Listing |
Publication Analysis
Top Keywords
metal-free formal
8
formal decarbonylation
8
aliphatic aldehydes
8
bioinspired metal-free
4
decarbonylation α-branched
4
α-branched aliphatic
4
aldehydes ambient
4
ambient temperature
4
temperature sequence
4
sequence baeyer-villiger
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!