Objective: To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images. In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group.

Methods: Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days. After this initial period, the animals were divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days. Micro-CT images were analyzed (conventional method and 3D reconstruction) on the 7th and 18th days following spring fixation and finally, 20 days after treatment either with CMT-3 or simvastatin (38th day). Bone mineral density (BMD) of the mesial and distal roots of the upper first molar was also analyzed.

Results: The difference was statistically significant between the groups as to recurrence (=0.048), and the post hoc test identified the value of =0.007 between the control group and the CMT-3 group. Simvastatin was not able to inhibit tooth relapse. The bone mineral densities of both the mesial and distal roots were different between the three groups, after the 20th day of drug use (=0001 and < 0001).

Conclusion: Our findings support the initial evidence that CMT-3 is able to prevent relapse after tooth movement. Future trials in humans should evaluate such treatment as a promising approach to preventing this common phenomenon.

Clinical Relevance: Considering the results obtained, CMT-3 can be used to avoid relapse after tooth movement.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466921PMC
http://dx.doi.org/10.1155/2019/3524207DOI Listing

Publication Analysis

Top Keywords

tooth relapse
12
tooth movement
12
novel analysis
8
chemically modified
8
modified tetracycline-3
8
tetracycline-3 cmt-3
8
relapse orthodontic
8
orthodontic movement
8
cmt-3 simvastatin
8
micro-ct images
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!