Background: Carbapenem-resistant Acinetobacter baumannii infections are a major public health problem worldwide, requiring the use of "old" antibiotics such as polymyxin B and E (colistin). However, there is concern regarding the emergence of isolates resistant to these antibiotics.
Case Presentation: We report a case of a 64-year-old mestizo man hospitalized in an intensive care unit of a health institution in Colombia with identification and clinical and molecular typing of a colistin- and carbapenem-resistant A. baumannii isolate with mechanisms of resistance to colistin not previously reported, causing bacteremia.
Conclusions: We have identified a strain of A. baumannii with mechanisms of resistance to colistin not previously reported in a patient with bacteremia who required treatment with multiple antibiotic schemes and had an adequate response.
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http://dx.doi.org/10.1186/s13256-019-2062-3 | DOI Listing |
Phytochem Anal
January 2025
Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Ciudad de México, Mexico.
Introduction: Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource.
Objectives: To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes associated with Mexican cloud forest ants by utilizing network analysis of their chemical and bioactivity data.
Front Cell Infect Microbiol
January 2025
Department of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with discrepant diagnostic performance. Additionally, there is still a lack of clinical data to reveal the association between pathogen loads detected by ddPCR and corresponding BSIs.
Methods: In this prospective study, 173 patients with suspected BSIs were enrolled.
Biol Res
January 2025
Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Rome, 00166, Italy.
Int J Biol Macromol
January 2025
LyseNTech Co., Ltd., Suite 1002, Innovalley C, 253 Pangyo-Ro, Bundang-Gu, Seongnam, Gyeonggi-Do 13486, Republic of Korea; Department of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yong-In, Gyeonggi-Do 17035, Republic of Korea; The Bacteriophage Bank of Korea, Suite 1002, Innovalley C, 253 Pangyo-Ro, Bundang-Gu, Seongnam, Gyeonggi-Do 13486, Republic of Korea. Electronic address:
Endolysins have drawn considerable attention as viable modalities for antibiotic use. The most significant obstacle for Gram-negative targeting endolysins is the presence of the outer membrane barrier. A heterologously expressed endolysin encoded by bacteriophage PBPA90 infecting Pseudomonas aeruginosa exhibited intrinsic antibacterial activity against P.
View Article and Find Full Text PDFInfect Drug Resist
January 2025
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Objective: This retrospective cohort study evaluated the treatment outcome of infection.
Methods: In this retrospective cohort study, 476 patients with () infection who were admitted to the internal medicine ward at Lampang Hospital, Lampang, Thailand, from 1 January 2020 to 31 December 2020 were enrolled. Medical records were reviewed.
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