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[Morphological characteristics and reduction techniques of sagittal beak-like deformity of head-neck fragment in femoral intertrochanteric fractures].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
June 2024
Department of Orthopedic Trauma, Yantaishan Hospital, Yantai Shandong, 264000, P. R. China.
Article Synopsis
- - The study examined 31 patients with femoral intertrochanteric fractures featuring a specific "sagittal beak-like" deformity, with an average age of 76.2 years, focusing on fracture morphology and reduction techniques from May 2021 to April 2023.
- - Fractures were classified using two systems: the AO/OTA classification and a new classification by the Chinese Rehabilitation Medical Association, revealing various types and complications in fracture morphology.
- - After unsuccessful closed reductions, all patients underwent surgical intervention using a minimal incision technique for secure internal fixation, with various metrics like operation time and complication rates measured to assess recovery outcomes.
Delayed Collagen Production without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds.
J Invest Dermatol
May 2024
Graduate Institute of Clinical Research, College of Medicine, National Taiwan University, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
In adult mammals, wound healing predominantly follows a fibrotic pathway, culminating in scar formation. However, cutaneous microwounds generated through fractional photothermolysis, a modality that produces a constellation of microthermal zones, exhibit a markedly different healing trajectory. Our study delineates the cellular attributes of these microthermal zones, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours.
View Article and Find Full Text PDFA Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.
J Invest Dermatol
September 2023
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. Electronic address:
Single-cell technologies have become essential to driving discovery in both basic and translational investigative dermatology. Despite the multitude of available datasets, a central reference atlas of normal human skin, which can serve as a reference resource for skin cell types, cell states, and their molecular signatures, is still lacking. For any such atlas to receive broad acceptance, participation by many investigators during atlas construction is an essential prerequisite.
View Article and Find Full Text PDFAmyloid-beta impairs TOM1-mediated IL-1R1 signaling.
Proc Natl Acad Sci U S A
October 2019
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697;
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the termination of IL-1β inflammatory responses by focusing on the role played by the target of Myb1 (TOM1), a negative regulator of the interleukin-1β receptor-1 (IL-1R1). We first show that TOM1 steady-state levels are reduced in human AD hippocampi and in the brain of an AD mouse model versus respective controls.
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