AI Article Synopsis
- Cervical cancer is a leading cause of mortality among reproductive-age women in the U.S., and abdominal radical trachelectomy (ART) is a procedure aimed at preserving fertility for those with early-stage cancer.
- A meta-analysis reviewed 5 studies involving 840 women to compare the outcomes of ART and radical hysterectomy (RH).
- Although ART took significantly longer to perform, both procedures showed similar 5-year survival and disease-free survival rates, indicating that ART is a viable option for women wanting to maintain their fertility while managing early-stage cervical cancer.
Article Abstract
Purpose: Cervical cancer (CC) ranks 2nd for mortality among women of reproductive age in the United States. Abdominal radical trachelectomy (ART) is a fertility sparing approach that has been proposed in women with early stage CC who wish to preserve their fertility. The aim of the present meta-analysis was to evaluate the short- and long-term outcomes of RH vs ART for early stage CC.
Methods: A total of 5 electronic databases were searched for articles published up to December 2018. Prospective and retrospective trials reporting outcomes for women who underwent ART or RH for the management of early stages CC, were considered eligible for inclusion. Statistical meta-analysis was performed using the RevMan 5.3 software.
Results: A total of 5 studies which included 840 women who underwent ART or radical trachelectomy (RH) were included in the present meta-analysis. Among them, 324 underwent ART whereas the remaining 516 had RH. Despite the fact that ART was associated with significantly prolonged operative time compared to RH (840 patients MD 36.82 min, 95% CI 20.15-53.49, p < 0.001), neither 5-year OS nor 5-year DFS were different among the two groups (714 patients OR 1.39, 95% CI 0.53-3.62, p = 0.51 and 682 patients OR 1.08, 95% CI 0.52-2.25, p = 0.84, respectively).
Conclusions: ART is a more complex and time consuming technique, but equally safe compared to RH in terms of oncological outcomes for selected women with early stage CC and allows for more CC survivors of childbearing age to preserve their fertility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00404-019-05176-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modified abdominal radical trachelectomy used to spare fertility during surgery for early-stage cervical cancer: a case report.
J Med Case Rep
November 2024
Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam.
Background: Cervical cancer is the fourth most common malignant tumor in childbearing-age women. To date, cervical resection and fertility-sparing surgery are the trends in the era of minimally invasive management. However, a proper management remains crucial.
View Article and Find Full Text PDFLaparoscopic Robotic Assisted Surgery in Reproductive Medicine.
Arch Med Res
December 2024
Department of Obstetrics and Gynecology, Southern Illinois University, Springfield, Illinois, USA. Electronic address:
Article Synopsis
- Laparoscopic Robot-assisted surgery is a cutting-edge advancement in surgical technology, particularly benefiting reproductive medicine by enhancing fertility and providing innovative treatment options for gynecological conditions.
- Compared to traditional open surgery, it offers reduced post-surgical hospital stays and blood loss, with mixed results on operative times due to varying surgeon experience.
- Despite challenges like high costs and lack of tactile feedback, recent improvements—including the integration of Artificial Intelligence—are enhancing its applications for fertility preservation in female cancer survivors and other reproductive surgeries.
Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report.
Cureus
October 2024
Obstetrics and Gynecology, Sapporo Medical University, Sapporo, JPN.
Vaginal trachelectomy, which involves resecting the cervix and its parametrium, is a fertility-sparing option for the treatment of early-stage cervical cancer. Although no consensus has been reached on whether simple or radical trachelectomy is preferable, the vaginal approach is typically avoided for tumors larger than 2 cm due to concerns about recurrence. However, some evidence suggests that fertility preservation may still be viable for select patients with larger tumors.
View Article and Find Full Text PDFFirst robotic radical trachelectomy for cervical cancer using the Hugo RAS platform.
Int J Gynecol Cancer
January 2025
Gynecology Oncology Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.
Eur J Surg Oncol
January 2025
Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy; PhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, Sassari, Italy.
Objective: We assessed reproductive, obstetrical, and oncological outcomes in patients who underwent fertility-sparing treatment by including studies that adhere to the FIGO 2018 staging system.
Methods: Data on recurrence, mortality, pregnancy rate, live birth rate, and preterm delivery rate were collected.
Results: In patients with stages IA1, IA2, and IB1, the recurrence rate was 4.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!