Background: Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.
Areas Covered: This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.
Conclusion: In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00404-019-05181-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Undifferentiated endometrial carcinoma diagnosed during perimenopausal hormone therapy: a case report and literature review.
Front Oncol
November 2024
The Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China.
Uterine corpus endometrial carcinoma, one of the three most frequent cancers of the female reproductive system, primarily affects women who are perimenopausal or postmenopausal. Moreover, it is an epithelial cancer that develops in the endometrium, which is classified as either estrogen-dependent (type I) or non-estrogen-dependent (type II). Non-estrogen-dependent endometrial cancers include plasma cell carcinoma and undifferentiated/dedifferentiated endometrial carcinoma.
View Article and Find Full Text PDFIntracellular autoactivation and surface location of hepsin, TMPRSS2, and TMPRSS13.
Life Sci
December 2024
Center for Human Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. Electronic address:
Aims: Hepsin (HPN), a Type II transmembrane serine protease (TTSP), is involved in hepatocyte metabolism and various diseases. It undergoes autoactivation on the surface of human hepatoma cells, a mechanism not observed in other cell types. This study aims to explore HPN activation and surface expression in endometrial epithelial cells.
View Article and Find Full Text PDFNCLN as a potential prognosis biomarker in endometrial cancer.
Heliyon
October 2024
Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Guangdong, China.
Endometrial cancer (ECs) stands as one of the three major malignancies impacting females globally, with its incidence steadily increasing. ECs can be categorized into two types based on their clinicopathological features. Type I ECs typically exhibit low stage, favorable histological types, and low histological grade, correlating with a more favorable prognosis.
View Article and Find Full Text PDFEndometrioid tubal intraepithelial neoplasia (E-TIN): case report & literature review.
J Mol Histol
November 2024
Department of Histopathology and Cytopathology, Cotman Centre, Norfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UB, UK.
An endometrioid carcinogenic pathway of the fallopian tube with possible potential precursors including type II SCOUTs (secretory cell outgrowths) and E-TIN (endometrioid tubal intraepithelial neoplasia) has been recently documented. We report an incidental focus of E-TIN identified in a hysterectomy specimen for Grade 1 endometrioid type endometrial carcinoma. The lesion was present at the fimbriated end of left fallopian tube involving 1 plica.
View Article and Find Full Text PDFDiscovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Proc Natl Acad Sci U S A
November 2024
Center for Drug Discovery, Baylor College of Medicine, Houston, TX 77030.
Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegic homolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also present in a subset of endometrial tumors, melanomas, non-small lung cancers, and colorectal cancers, and ALK2 expression is elevated in pancreatic cancer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!