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5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation.
Int J Mol Sci
November 2024
School of Life Sciences, Central South University, Changsha 410031, China.
Epigenetics plays a pivotal role in regulating gene expression and cellular differentiation. DNA methylation, involving the addition of methyl groups to specific cytosine bases, is a well-known epigenetic modification. The recent discovery of 5-hydroxymethylcytosine (5hmC) has provided new insights into cytosine modifications.
View Article and Find Full Text PDFAdvances in high throughput sequencing methods for DNA damage and repair.
Yi Chuan
October 2024
Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Article Synopsis
- High-throughput sequencing technology has rapidly advanced, leading to various methods for detecting different types of DNA damage.
- These techniques enhance our understanding of DNA repair pathways, key biological processes, and identify new damage hotspots, which can contribute to disease research and drug development.
- The article reviews major sequencing methods for DNA lesions, explaining their principles to help researchers choose the right techniques effectively.
Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications.
PLoS Genet
September 2024
Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Lytic bacteriophages hold substantial promise in medical and biotechnological applications. Therefore a comprehensive understanding of phage infection mechanisms is crucial. CRISPR-Cas systems offer a way to explore these mechanisms via site-specific phage mutagenesis.
View Article and Find Full Text PDFEngineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos.
Mol Cell
August 2024
Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address:
The IscB proteins, as the ancestors of Cas9 endonuclease, hold great promise due to their small size and potential for diverse genome editing. However, their activity in mammalian cells is unsatisfactory. By introducing three residual substitutions in IscB, we observed an average 7.
View Article and Find Full Text PDFevaluation of antifungal combinations against neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosis.
Microbiol Spectr
August 2024
Department of Microbiology, ICMR-Advanced Mycology Diagnostic and Research Centre, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Primary cerebral phaeohyphomycosis is a life-threatening disease caused by neurotropic dematiaceous fungi. At present, there are no consensus guidelines regarding optimal antifungal therapy in such cases. Generally, a combination of antifungal agents is recommended for treatment.
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