The Michael reaction of malonates with maleates afforded the corresponding adducts in high yields with high enantioselectivities (up to 98% enantiomeric excess (ee)) by using dilithium 3,3'-dichlorobinaphtholate as a catalyst. The obtained Michael adducts could be converted to optically active tricarboxylic acid (TCA) derivatives via the Krapcho reaction.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1248/cpb.c18-00993 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!