AI Article Synopsis
- - The symposium review discusses analytical methods for rapidly identifying toxic chemical warfare agents, particularly nerve gases, to counter terrorism threats.
- - For high-level nerve gas exposure, a technology that detects nerve gas hydrolysis products using advanced gas chromatography-mass spectrometry (GC-MS) is highlighted.
- - For low-level exposure, two methods are described that detect nerve gas adducts with blood cholinesterase: one involves enzymatic digestion with liquid chromatography/mass spectrometry (LC/MS), and the other uses solid phase extraction with GC-MS.
Article Abstract
As a countermeasure against terrorism involving highly toxic chemical warfare agents, the rapid identification of the causative toxic substances is extremely important. This symposium review describes analytical methods the author's group has developed for detecting nerve gases after either high level or low level exposure. As a method for assessing human exposure to high levels of nerve gases, a technology that detects nerve gas hydrolysis products, i.e., strong anion exchange extraction-tert-butyldimethylsilyl derivatization-selectable one-dimensional or two-dimensional GC-MS, is explained. As a method for assessing human exposure to low levels of nerve gases, two technologies that detect adducts of nerve gas with blood cholinesterase, i.e., adduct purification-enzymatic digestion-LC/MS and fluoride-mediated regeneration-solid phase extraction-large volume introduction GC-MS, are explained.
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| http://dx.doi.org/10.1248/yakushi.18-00166-5 | DOI Listing |
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