Discounting refers to the way in which the value of an outcome depends on the delay until it is obtained. If an organism's discount function is known, then its rate of discounting at any delay can be found. If the function is not known, the normalised area under an estimate of the discount function has been used as a measure that summarises the strength of discounting over a range of delays. We propose a new measure of the strength of discounting: the overall discount rate W, which is the drop in value from the start to the end of the value curve divided by the area under this curve. We show that our measure has various advantages over the normalised area, namely it can be linked to the instantaneous rate of discounting and it respects the special nature of exponential discounting. It does not give a unique value to each curve, but we prove that this is incompatible with the requirement that similar discount functions be assigned similar values, and so this is not a defect of the measure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.beproc.2019.05.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dihydropyrimidine Dehydrogenase Deficiency (DPYD) Genotyping-Guided Fluoropyrimidine-Based Adjuvant Chemotherapy for Breast Cancer. A Cost-Effectiveness Analysis.
Clin Drug Investig
January 2025
Pharmacy Department, Hamad Medical Corporation, Doha, 3050, Qatar.
Background And Objective: While standard doses of adjuvant fluoropyrimidine-based chemotherapies are generally safe for most patients, the risk of severe adverse drug reactions (ADRs) is increased for those with dihydropyrimidine dehydrogenase deficiency (DPYD), a genetic variation that affects drug metabolism. The objective of this study was to examine the cost effectiveness of offering DPYD pharmacogenetic-guided care, where genetic testing informs personalized dosing versus the current standard of care (SoC), which involves administering fluoropyrimidine-based therapies without prior genetic screening, for local or metastatic breast cancer patients in Qatar.
Methods: We developed a two-stage decision analysis, with an analytic tree model over a 6-month period, followed by a life-table Markov model over a lifetime horizon.
Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding.
ACS Infect Dis
January 2025
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD site.
View Article and Find Full Text PDFMultispecies fisheries management of the Sultanate of Oman using bioeconomic model.
Heliyon
January 2025
Sultan Qaboos University, College of Agricultural and Marine Sciences, Department of Natural Resource Economics, Sultanate of Oman.
A bioeconomic analysis using the Gordon-Schafer surplus production model was conducted on Indian mackerel (), Yellowfin tuna (), Kingfish (), and Indian Oil Sardine () based on data from the Ministry of Agriculture, Fisheries, Wealth, and Water Resources of Oman from 1990 to 2020. The alignment of biological and economic yields with the ideal fishing efforts needed to attain maximum sustainable yield (MSY) and maximum economic yield (MEY) was considered in order to evaluate the economic efficiency of existing fisheries management. The long-term sustainability of Oman's fisheries is improved by this analysis, which identifies inefficiencies in resource use and suggests viable remedies.
View Article and Find Full Text PDFBackground: Childhood cancer is not a high priority in health care financing for many countries, including in Ghana. Delayed care seeking and treatment abandonment, often due to the financial burden of care seeking to families, are common reasons for a relatively low overall survival (OS) in low-and middle-income countries. In this study, we analyzed the cost-effectiveness of extending health insurance coverage to children with Burkitt lymphoma (BL) in Ghana.
View Article and Find Full Text PDFThe Impact of Data Control and Delayed Discounting on the Public's Willingness to Share Different Types of Health Care Data: Empirical Study.
JMIR Med Inform
January 2025
School of Management, Zhengzhou University, Zhengzhou, China.
Background: Health data typically include patient-generated data and clinical medical data. Different types of data contribute to disease prevention, precision medicine, and the overall improvement of health care. With the introduction of regulations such as the Health Insurance Portability and Accountability Act (HIPAA), individuals play a key role in the sharing and application of personal health data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!