AI Article Synopsis
- The study introduces a method for adding γ,γ,γ-trifluoroalkyl groups to quinolines using visible light, without the need for a photocatalyst.
- The process uses common alkenes and Umemoto's reagent II, allowing for the selective incorporation of various trifluoroalkyl groups via radical reactions.
- This approach provides easy access to new quinoline derivatives that can serve as valuable components in medicinal chemistry research.
Article Abstract
The photocatalyst-free C-H γ,γ,γ-trifluoroalkylation of quinolines under visible light irradiation is reported. By the combination of readily available alkenes and Umemoto's reagent II, a variety of γ,γ,γ-trifluoroalkyl groups were installed into quinolines via chemoselective sequential radical processes. This transformation provides rapid access to a variety of quinoline derivatives with scarcely explored fluoroalkyl groups, affording a novel library of N-heteroaromatic compounds and versatile building blocks for applications in medicinal chemistry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.9b01015 | DOI Listing |
Publication Analysis
Top Keywords
c-h γγγ-trifluoroalkylation
8
γγγ-trifluoroalkylation quinolines
8
sequential radical
8
quinolines visible-light-induced
4
visible-light-induced sequential
4
radical additions
4
additions photocatalyst-free
4
photocatalyst-free c-h
4
quinolines visible
4
visible light
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!