A novel approach to α-amino-α-cyanophosphonates has been developed. The method features a TfO-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale.
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| http://dx.doi.org/10.1021/acs.orglett.9b01257 | DOI Listing |
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