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| http://dx.doi.org/10.3389/fnagi.2019.00093 | DOI Listing |
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Automatic segmentation of white matter lesions on multi-parametric MRI: convolutional neural network versus vision transformer.
BMC Neurol
January 2025
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, School of Medicine, College of Medicine, National Sun Yat-Sen University, No. 123 Ta-Pei Road, Niao-Sung Dist, Kaohsiung, 83305, Taiwan.
Background And Purpose: White matter hyperintensities in brain MRI are key indicators of various neurological conditions, and their accurate segmentation is essential for assessing disease progression. This study aims to evaluate the performance of a 3D convolutional neural network and a 3D Transformer-based model for white matter hyperintensities segmentation, focusing on their efficacy with limited datasets and similar computational resources.
Materials And Methods: We implemented a convolution-based model (3D ResNet-50 U-Net with spatial and channel squeeze & excitation) and a Transformer-based model (3D Swin Transformer with a convolutional stem).
Immunohistochemical labeling of ongoing axonal degeneration 10 days following cervical contusion spinal cord injury in the rat.
Spinal Cord
January 2025
McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Study Design: Experimental Animal Study.
Objective: To continue validating an antibody which targets an epitope of neurofilament light chain (NF-L) only available during neurodegeneration and to utilize the antibody to describe the pattern of axonal degeneration 10 days post-unilateral C4 contusion in the rat.
Setting: University of Florida laboratory in Gainesville, USA.
Impact of white matter hyperintensity location on outcome in acute ischemic stroke patients: a lesion-symptom mapping study.
Brain Imaging Behav
January 2025
Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background: Studies on the impact of white matter hyperintensity (WMH) on function outcome have primarily concentrated on WMH volume, overlooking the potential significance of WMH location. This study aimed to investigate the relationship between WMH location and outcome in patients with their first-ever acute ischemic stroke (AIS).
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The two sides of Phobos: Gray and white matter abnormalities in phobic individuals.
Cogn Affect Behav Neurosci
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Departamento de Psicología ClínicaPsicobiología y MetodologíaFacultad de Psicología, Universidad de La Laguna, La Laguna, 38200, Tenerife, Spain.
Small animal phobia (SAP) is a subtype of specific phobia characterized by an intense and irrational fear of small animals, which has been underexplored in the neuroscientific literature. Previous studies often faced limitations, such as small sample sizes, focusing on only one neuroimaging modality, and reliance on univariate analyses, which produced inconsistent findings. This study was designed to overcome these issues by using for the first time advanced multivariate machine-learning techniques to identify the neural mechanisms underlying SAP.
View Article and Find Full Text PDFRadiological markers of CSF α-synuclein aggregation in Parkinson's disease patients.
NPJ Parkinsons Dis
January 2025
Movement Disorders Unit, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel.
Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson's disease (PD) and can be detected through synuclein amplification assays (SAA). This study investigated the association between cerebrospinal fluid (CSF) radiological measures in 41 PD patients (14 iPD, 14 GBA1-PD, 13 LRRK2-PD) and 14 age-and-sex-matched healthy controls. Quantitative measures including striatal binding ratios (SBR), whole-brain and deep gray matter volumes, neuromelanin-MRI (NM-MRI), functional connectivity (FC), and white matter (WM) diffusion-tensor imaging (DTI) were calculated.
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