AI Article Synopsis
- In a study of infants in Nepal, 75.5% of those with respiratory illnesses had pneumococcus detected in their nasal passages.
- Pneumococcal carriage did not affect the severity of lower respiratory diseases caused by influenza, RSV, or hMPV.
- Infants born to mothers who received the influenza vaccine had lower pneumococcal carriage rates than those born to mothers who did not receive the vaccine.
Article Abstract
In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688054 | PMC |
| http://dx.doi.org/10.1093/infdis/jiz212 | DOI Listing |
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