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http://dx.doi.org/10.15537/smj.2019.5.24078 | DOI Listing |
Background: For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined with cisplatin nearly universally results in death. Although hyperactivation of the Nrf2 pathway can drive radiation and cisplatin resistance along with suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary to synergistic lethality with other oncogenic drivers (e.g.
View Article and Find Full Text PDFSmall
January 2025
Helmholtz Institute Ulm (HIU), Helmholtzstrasse 11, 89081, Ulm, Germany.
Separators are critical components of zinc-metal batteries (ZMBs). Despite their high ionic conductivity and excellent electrolyte retention, the widely used glass fiber (GF) membranes suffer from poor mechanical stability and cannot suppress dendrite growth, leading to rapid battery failure. Contrarily, polymer-based separators offer superior mechanical strength and facilitate more homogeneous zinc (Zn) deposition.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
Emergency Medicine, Vanderbilt University Medical Center and, Veterans Affairs Tennessee Valley Healthcare System, Geriatric Research, Education and Clinical Center (GRECC), Nashville, TN, USA.
Background: Heart failure is a major public health concern, affecting 6.7 million Americans. An estimated 16% of emergency department (ED) patients with acute heart failure (AHF) are discharged home.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Chair of Metal Forming and Casting, Technical University of Munich, Walther-Meissner-Strasse 4, 85748 Garching, Germany.
Deep drawing is a cost-efficient way of producing sheet metal parts in high production volumes. Prototypes and very small series are expensive due to the cost of steel-forming tools. Ultra-high-performance concrete (UHPC) tools offer a cheap and fast alternative to conventional steel-forming tools.
View Article and Find Full Text PDFActa Biomater
January 2025
Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands.
Many cardiovascular events are triggered by fibrous cap rupture of an atherosclerotic plaque in arteries. However, cap rupture, including the impact of the cap's structural components, is poorly understood. To obtain better mechanistic insights in a biologically and mechanically controlled environment, we previously developed a tissue-engineered fibrous cap model.
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