Host Genetics, Diet, and Microbiome: The Role of AMY1.

Trends Microbiol

Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico. Electronic address:

Published: June 2019

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics-diet-microbiome interactions and their effect on obesity could eventually translate into personalized nutrition.

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http://dx.doi.org/10.1016/j.tim.2019.04.001DOI Listing

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