AI Article Synopsis
- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression by binding to specific regions of target mRNAs.
- In a study comparing plasma levels of miR-210-3p and miR-517c-3p between preeclamptic women and healthy controls, it was found that these miRNAs were significantly elevated in preeclampsia cases.
- This research, which is the first to measure miR-517c in preeclampsia using real-time PCR, suggests potential new avenues for understanding the causes of preeclampsia and identifying new biomarkers for the condition.
Article Abstract
MicroRNAs (miRNAs, miRs) are small regulatory non-coding RNAs that regulate gene expression by incomplete complementary attachment to the 3'UTR, 5'UTR, ORF and promoter regions of target mRNAs. We compared plasma levels of miR-210-3p and miR-517c-3p as cell-free microRNAs (cfmiRNAs) in preeclamptic (n = 20) and healthy women (n = 20). These miRs are responsible for cell growth and proliferation, placental hypoxia, immune response and apoptosis. We found higher expression levels of miR-210 and miR-517c in preeclamptic cases (+3.34 and +2.27 fold change, respectively). This is the first study that evaluates the plasma levels of miR-517c in preeclamptic cases by real time PCR (RT-PCR) technique. This study can lead to new opportunities for research about the roles of miRNAs in preeclampsia etiology or new biomarkers.
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| http://dx.doi.org/10.1016/j.preghy.2019.03.004 | DOI Listing |
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