We investigated the activity of roxithromycin (RU 965) and gamma interferon alone and in combination in a murine model of toxoplasmic encephalitis. Roxithromycin at a dosage of 35 or 50 mg per mouse per day decreased mortality. Gamma interferon alone significantly prolonged time to death. When combined, the two agents were remarkably synergistic.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174724 | PMC |
| http://dx.doi.org/10.1128/AAC.31.2.346 | DOI Listing |
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