Purpose: To evaluate the effect of image registration on the diagnostic performance of transfer learning (TL) using pretrained convolutional neural networks (CNNs) and three-phasic dynamic contrast-enhanced computed tomography (DCE-CT) for primary liver cancers.
Methods: We retrospectively evaluated 215 consecutive patients with histologically proven primary liver cancers, including six early, 58 well-differentiated, 109 moderately differentiated, 29 poorly differentiated hepatocellular carcinomas (HCCs), and 13 non-HCC malignant lesions containing cholangiocellular components. We performed TL using various pretrained CNNs and preoperative three-phasic DCE-CT images. Three-phasic DCE-CT images were manually registered to correct respiratory motion. The registered DCE-CT images were then assigned to the three color channels of an input image for TL: pre-contrast, early phase, and delayed phase images for the blue, red, and green channels, respectively. To evaluate the effects of image registration, the registered input image was intentionally misaligned in the three color channels by pixel shifts, rotations, and skews with various degrees. The diagnostic performances (DP) of the pretrained CNNs after TL in the test set were compared by three general radiologists (GRs) and two experienced abdominal radiologists (ARs). The effects of misalignment in the input image and the type of pretrained CNN on the DP were statistically evaluated.
Results: The mean DPs for histological subtype classification and differentiation in primary malignant liver tumors on DCE-CT for GR and AR were 39.1%, and 47.9%, respectively. The highest mean DPs for CNNs after TL with pixel shifts, rotations, and skew misalignments were 44.1%, 44.2%, and 43.7%, respectively. Two-way analysis of variance revealed that the DP is significantly affected by the type of pretrained CNN (P = 0.0001), but not by misalignments in input images other than skew deformations.
Conclusion: TL using pretrained CNNs is robust against misregistration of multiphasic images and comparable to experienced ARs in classifying primary liver cancers using three-phasic DCE-CT.
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http://dx.doi.org/10.1007/s11548-019-01987-1 | DOI Listing |
Hepatol Commun
November 2024
Department of Medicine, University of California, San Diego, La Jolla, California, USA.
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View Article and Find Full Text PDFExpert Rev Gastroenterol Hepatol
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California San Diego, San Diego, CA.
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January 2025
Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany.
SARS-CoV-2 infection is accompanied by elevated liver enzymes, and patients with pre-existing liver conditions experience more severe disease. While it was known that SARS-CoV-2 infects human hepatocytes, our study determines the mechanism of infection, demonstrates viral replication and spread, and highlights direct hepatocyte damage. Viral replication was readily detectable upon infection of primary human hepatocytes and hepatoma cells with the ancestral SARS-CoV-2, Delta, and Omicron variants.
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Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.
Aim: We previously reported that abdominal aortic calcification is associated with poor overall and recurrence-free survival after hepatectomy for hepatocellular carcinoma (HCC). However, the effect of abdominal aortic calcification on cancer-specific prognosis in very old patients with several comorbidities remains unknown. This multicenter study aimed to evaluate the impact of abdominal aortic calcification on the cumulative recurrence rate and recurrence-free survival in patients with HCC aged >80 years.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Bialystok, Poland.
The growing burden of metabolic disorders manifested by hypertension, type 2 diabetes mellitus, hyperlipidemia, obesity and non-alcoholic fatty liver disease presents a significant global health challenge by contributing to cardiovascular diseases and high mortality rates. Β-blockers are among the most widely used drugs in the treatment of hypertension and acute cardiovascular events. In addition to blocking the receptor sites for catecholamines, third-generation β-blockers with associated vasodilating properties, such as carvedilol and nebivolol, provide a broad spectrum of metabolic effects, including anti-inflammatory and antioxidant properties and a favorable impact on glucose and lipid metabolism.
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