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Efficacy of melatonin for treatment and prevention of neonatal necrotizing enterocolitis: a systematic review.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Departments of Pediatrics, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
The purpose of this study was to systematically review the available literature evaluating the use of melatonin for preventing and treating neonatal necrotizing enterocolitis (NEC). A systematic review of studies examining the effect of melatonin on neonatal NEC was conducted. The databases of Medline, Scopus, WOS, Embase, and Cochrane Central Register of Controlled Trials were searched for relevant studies.
View Article and Find Full Text PDFSerum electrolytes in children with heart failure on diuretic therapy at Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania: a cross-sectional study.
Pan Afr Med J
December 2024
Department of Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Introduction: diuretic therapy is among the cornerstones of the management of heart failure in children with acquired or congenital heart diseases (CHD). Electrolyte derangements have been reported by various studies to be among the most common side effects following diuretic therapy. Despite that, there is limited documentation on the magnitude of this problem in our setting.
View Article and Find Full Text PDFCeasing or gradually reducing incubator humidity after 7 days for extremely preterm infants: a randomised clinical trial.
Eur J Pediatr
December 2024
Grantley Stable Neonatal Unit (GSNU), Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, Australia.
Unlabelled: The purpose of this study is to compare the effects of two different ways of stopping incubator humidification on episodes of hypothermia, hyperthermia, hyponatraemia, hypernatraemia, or skin injury. The design is a single site, two-armed, parallel, randomised, clinical trial conducted between April 2019 and March 2022. The setting was a quaternary referral and teaching hospital in Queensland, Australia.
View Article and Find Full Text PDFRenal pseudohypoaldosteronism type 1-an adult case series including a novel gene variant.
Endocrine
November 2024
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
Article Synopsis
- Renal pseudohypoaldosteronism type 1 (PHA1) is a rare condition mainly affecting infants, resulting in symptoms like vomiting and weight loss due to dysfunctional mineralocorticoid receptors caused by gene variants in NR3C2.
- A study on four adults with PHA1 revealed they had elevated plasma aldosterone but normal sodium levels, with one individual showing increased plasma renin.
- The findings suggest that PHA1 is asymptomatic in adulthood, and individuals often have favorable long-term health outcomes.
Association between hyponatremia and disease severity in pediatric urinary tract infections.
BMC Pediatr
November 2024
Department of Pediatrics, Chi Mei Medicine Center, No. 901, Zhonghua Road., Yongkang Dist, Tainan City, 710402, Taiwan.
Article Synopsis
- Acute urinary tract infections (UTIs) are common in children, affecting about 8% of girls and 2% of boys by age 7, with serious cases leading to acute pyelonephritis (APN).
- A study reviewed data from 344 pediatric UTI/APN patients treated from 2012 to 2022, categorizing them by serum sodium levels (hyponatremia vs. eunatremia).
- Results showed that patients with hyponatremia had higher instances of APN and abnormal kidney scans, suggesting hyponatremia might indicate a more severe UTI, although further research is needed to understand its implications.
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